Tramadol is a synthetic opioid analgesic with a dual mechanism of action. This drug has a strong analgesic activity that allows to use it for rapid relief of acute and chronic pain of moderate to severe intensity.
Tramadol is used to treat chronic pain in patients to whom non-opioid analgesics no longer help to cope with severe pain. Indications for Tramadol use are as follows:
- Pain syndrome in cancer patients;
- Postoperative pain syndrome;
- Neuropathic pain syndrome;
- Post-traumatic pain syndrome.
First, Tramadol was approved as a non-controlled analgesic in 1995. However, because of increased cases of abuse, this analgesic has been included in Schedule IV controlled substances since 2014.
Patients, who require treatment of chronic non-cancer pain, can buy Tramadol at pharmacy chains or on online pharmacies.
Before to buy Tramadol, it is necessary to ask the doctor what doses of this analgesic to use to relieve pain and how long to take this antibiotic.
Patients, who order Tramadol online, can get information from a pharmacist about this analgesic. Online pharmacies take orders for delivery of analgesic medicines around the clock. Therefore, potential buyers can get reliable information about Tramadol at any convenient time.
Most online pharmacies work directly with pharmaceutical manufacturing companies of opioid analgesics. Therefore, they offer the best price for Tramadol and provide wholesale and retail buyers with discounts.
That is why Tramadol price is reasonable on online pharmacy and more and more people prefer to order this medicine for pain treatment on the Internet.
Online pharmacies provide next day delivery of analgesics at home or workplace. Thus, potential buyers can order Tramadol without leaving home or office.
Regardless of whether you bought Tramadol online or at retail pharmacy, carefully read the analgesic leaflet before using it.
After reading the leaflet for Tramadol use, you will learn how this analgesic work and how to take it.
Despite the fact that Tramadol belongs to opioid analgesics, the drug is advantageously distinguished by its dual mechanism of action.
- Firstly, this analgesic quickly binds to mu opioid receptors in the CNS, inhibits transmission of nerve impulses. Due to such mechanism of action, pain impulses are weakened or interrupted.
- Secondly, Tramadol activates the noradrenergic and serotonergic systems and inhibits transmission of pain impulses to neurons of the spinal cord.
At the US market, Tramadol is supplied as oral tablets and extended-release capsules. Tramadol is sold under the trade names Ultram, Ryzolt, and ConZip at pharmacies.
Analgesic effect of Tramadol develops 15-30 minutes after intake. The analgesic effect lasts up to 6 hours. Dosage regimen of Tramadol is selected depending on the patient’s condition.
In general, the initial dose is 25-50 mg of Tramadol once daily. Then every three days, Tramadol dose is increased by 25 mg until the required analgesic effect is obtained. The maximum dose should not exceed 300-400 mg of Tramadol per day.
Tramadol should not be administered for longer than it is therapeutically necessary. Abuse of this analgesic can lead to development of side effects and drug dependence.
Tramadol is prescribed with caution to patients with impaired renal and hepatic functions, as well as with craniocerebral trauma and increased intracranial pressure. Tramadol is not recommended for children and adolescents under 18 years of age.