Cymbalta is the representative of the latest generation of antidepressants. The introduction of the drug into clinical practice significantly increased the potential for the treatment of major depressive disorder (MDD). Diabetic patients can buy and use Cymbalta to alleviate the neuropathic pain, associated with diabetes.
The advantages of Cymbalta in the treatment of depressive disorders and neuropathic pain:
- Fast onset of therapeutic effect;
- Minimum frequency of administration (once a day);
- Good tolerability in elderly patients over 65 years of age;
- Arresting of pain symptoms, associated with depressive disorders;
- Reduces the severity of intractable symptoms of depression, like asthenia, sleep disorders and others.
Cymbalta belongs to the therapeutic class of selective serotonin reuptake inhibitors (SSRI). A distinctive feature of Cymbalta vs the rest of SSRI is that this antidepressant almost does not bind to any other receptors, except serotonin receptors.
Cymbalta has a central action mechanism for suppressing the pain syndrome. The analgesic effect of the drug manifests through an increase in the threshold of pain sensitivity and a decrease in emotional suffering.
To get the medicine in a regular pharmacy, patients need a prescription from the attending physician. However, if you use one of the online pharmacies, you can buy Cymbalta without a prescription.
The drug form of Cymbalta is a capsule filled with enteric coated granules. The contents of each capsule can be equivalent to 20 mg, 30 mg or 60 mg of the active substance Duloxetine.
Granules with enteric coating are a specially developed dosage form, which contributes to an improvement in the therapeutic effectiveness of Cymbalta. The coating of the granules protects the drug substance from the harmful effects of the acidic environment of the stomach.
Therefore, after the ingestion, Cymbalta capsule dissolves in the intestine, and not in the stomach. This promotes a selective release of Duloxetine, increased stability and improvement in the absorption of the drug substance.
The dosage of Cymbalta is:
- For the treatment of neuropathic pain: 60 mg once a day;
- For the treatment of MDD: 40-60 mg once a day, or divided into two intakes.
The antidepressant effect of Cymbalta develops towards the end of the second week of use. A marked decrease in symptoms of MDD occurs after 4-6 weeks of therapy. The maximum duration of Cymbalta use should not exceed 9 weeks.
Cymbalta is not the first and not the only antidepressant from the SSRI group. The drug was developed in 1986 by researchers from the pharmaceutical company Eli Lilly.
Duloxetine was patented four years later. But the introduction of the antidepressant into clinical practice was postponed for many years. The researchers assessed the antidepressant activity of Cymbalta as not being high enough to relieve the patient of mental disorders.
It took almost 15 years before clinical studies confirmed the effectiveness of high Cymbalta doses in the treatment of mental disorders. On August 3, 2004, the drug was approved by the FDA for the treatment of MDD and neuropathic pain.
Cymbalta is the most popular, yet not the only Duloxetine brand. The antidepressant is sold under such brand names, as Nitidex, Xeristar, Alacir, Duceten, Nilodux, Yentreve, Ariclaim and others.
As of today, the price of Cymbalta in pharmacies remains quite high. Many patients, especially without medical insurance, can not afford to buy this antidepressant because of its high cost. To save money, patients can buy cheap Cymbalta online.
In addition, the patent protection period of Cymbalta expired in 2013, and the antidepressant appeared on sale under a generic name. Cymbalta generic drugs are cheaper than the original drug, since the formula of the active ingredient Duloxetine has already been developed and no additional financial costs are required for the drug development.