Clomid and Nolvadex are hormonal drugs that are used in clinical practice to treat the female reproductive system diseases. Clomid is used in the therapy of female infertility, Nolvadex – in antitumor therapy of breast cancer.
Clomid and Nolvadex are anti-estrogens. That is, in small doses they reduce the content of female sex hormones, estrogens, and, by the feedbackprinciple, increase the secretion of testosterone, the main male sex hormone.
Testosterone is the main anabolic hormone that is needed for protein synthesis and muscle mass gain. Therefore, when the level of testosterone lowers, men’s muscle mass decreases.
Clomid vs Nolvadex: effects in testosteroneincreasing
Clomid specifically binds to estrogen receptors in the hypothalamus. Its active ingredient, Clomiphene, stimulates the production of male sex hormones by reducing the concentration of estrogens. The benefits of Clomid in increasing testosterone and increasing muscle mass:
- has an anabolic effect
- increases the ability of muscles to absorb glucose as their energy source
- stimulates the production of gonadotropin, which protects muscles from catabolism
Additional benefits of Clomid are improved spermatogenesis and reduced symptoms of hypogonadism.
The therapeutic effect of Nolvadex is similar to that of Clomid. It interferes with the formation of the receptor-hormone complex. Its active ingredient Tamoxifen has the ability to competitively bind with estrogen receptors, thereby inhibiting their activity and inhibiting the production of female sex hormones.
To increase its efficacy, Nolvadex can be taken with steroids. Nolvadex prevents the effect of aromatization (conversion of testosterone to estrogens), characteristic of many anabolic steroids. An additional advantage of Nolvadex is the burning of fat deposits, which leads to an increase in muscle mass.
Clomid vs Nolvadex: dosage and method of administration
To increase the level of testosterone and build muscle mass, it is sufficient to take 25 mg of Clomid daily for 3 months. Testosterone levelsshould be regularly monitoredduring the period of Clomid use.
Active production of testosterone occurs with a daily intake of 10-20 mg of Nolvadex. The duration of useis selectedindividually for each athlete. Once the results of laboratory studies confirm that testosterone has reached the level, required for protein synthesis, Nolvadex can be stopped.
Clomid vs Nolvadex: safety and side effects
Both drugs can cause such side effects, as nausea, vomiting, visual impairment, soreness in the testicles or skin allergic reactions. Yet neither Clomid nor Nolvadex cause unwanted reactions that would threaten health or lead to discontinuation of the drugs.
- Conclusion: Clomid blocks estrogen receptors only in the hypothalamus, which stimulates Testosterone production.
- Nolvadex inhibits the activity of estrogen receptors located in the urethra, the mammary gland, the liver and the pituitary gland.
Since Clomid has a greater selectivity to estrogen receptors, it is more effective in increasing testosterone levels than Nolvadex.